Some Mechanisms Of Neurohumoral Regulation In Acute Chemical Trauma

Abstract

The study of extreme body states is one of the most important problems of modern biology and medicine. In fact, the release of hormones and biologically active substances marks the launch of the extreme body state response syndrome and controls all circulatory and metabolic processes in the body, ultimately leading to adaptation to changing environmental conditions. The production of biologically active substances affecting the function of other organs or systems, fully consistent with the concept of a hormone, occurs in the neuroendocrine cells of the socalled APUD system. The present study aimed to research the response of some of the APUD system peptides, namely neurotensin (N), substance P (SP), and vasoactive intestinal polypeptide (VIP), to acute chemical injury caused by poisoning with corrosive substances. The obtained data demonstrate that acute poisoning with corrosive substances causes a sharp and rapid response of the APUD system bioactive substances.

VIP, SP, and N are known to act as vasoconstrictors on blood vessels in high concentrations, which is more than necessary in cases of acute chemical trauma, since along with other similar substances (renin-angiotensinaldosterone system), they are involved in hypovolemia and hypotension compensation, and SP is a mediator of pain, hence preconditioning its very high concentration